Journal: ACS biomaterials science & engineering
Article Title: Microscopic Assessment of Healing and Effectiveness of a Foam-Based Peripheral Occlusion Device
doi: 10.1021/acsbiomaterials.9b00895
Figure Lengend Snippet: X-ray images of vessels implanted with the three types of occlusion devices tested in this study. (A) Right renal artery implanted with the Amplatzer Vascular Plug for 30 days. (B) Left internal thoracic artery implanted with Nester Embolization Coils for 30 days. (C) Right renal artery implanted with IMPEDE Embolization Plug for 60 days. In the radiographs, red lines indicate the proximal, middle, and distal sections targeted for histological evaluation. Note: For Nester and IMPEDE devices, two middle regions (proximal-mid, distal-mid) were selected for histological evaluation. Corresponding histological cross sections are displayed in order from proximal (left) to distal (right). Middle cross sections were divided into outer (yellow asterisk), mid (green asterisk), and central (pink diamond) regions for additional inflammatory cell count analysis. The scale bar in each histology cross section is 0.4 mm; stain: Hematoxylin and Eosin (H&E).
Article Snippet: Standard occlusion devices include fibered platinum coils such as Nester Embolization Coils (Cook Medical, Inc., Bloomington, IN) and the Amplatzer Vascular Plug (AVP) developed by AGA Medical, which consists of a single or multilayer nitinol mesh cage delivered via catheter that provides multiple occlusive planes along the length of the device.
Techniques: Cell Counting, Staining